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Prurigo Nodularis
Buy-and-Bill

Patient Considerations for New Systemic Treatments for Prurigo Nodularis : Episode 3

Opinion

Video

December 16, 2024

New Systemic Treatments for Prurigo Nodularis

Author(s):

Melodie Young, MSN, ANP-C

Key Takeaways

Prurigo nodularis diagnosis is challenging due to symptom overlap with other pruritic conditions and absence of specific tests.
Increased prevalence is noted in patients with atopic dermatitis and other specific subtypes.
Differentiation involves evaluating characteristic nodules, chronic itch, and potential underlying systemic conditions.
Accurate diagnosis requires thorough examination and consideration of differential diagnoses.

Melodie Young, MSN, A/GNP-C, discusses how the FDA-approved systemic treatments for prurigo nodularis, dupilumab and nevolizumabnemolizumab, differ in their mechanisms of action—dupilumab targeting IL-4 and IL-13, and nevolizumabnemolizumab targeting IL-31—and highlights their similar efficacy in reducing pruritus and lesion size, while also considering differences in safety profiles and treatment considerations.

EP: 1.Prurigo Nodularis Burden of Disease

EP: 2.Challenges in Diagnosing Prurigo Nodularis and Distinguishing From Other Pruritic Conditions

Now Viewing

EP: 3.New Systemic Treatments for Prurigo Nodularis

EP: 4.Talking to Patients About Itch Management

EP: 5.Provider and Patient Considerations for Prurigo Nodularis Treatment

EP: 6.The Burden of Prurigo Nodularis

Video content above is prompted by the following:

5. Two systemic treatments are now FDA-approved for prurigo nodularis: dupilumab and nevolizumabnemolizumab. Can you briefly discuss these two 2 agents, including similarities/differences as well as efficacy and safety?