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Opinion

Video

Discussing Efficacy and Safety of JAK Inhibitors With Patients and Caregivers

An expert discusses how alopecia areata significantly affects adolescent mental health. Treatment with ritlecitinib requires proper severity assessment via Severity of Alopecia Tool (SALT) score, clear communication of realistic timelines and goals, careful monitoring, and discussion of potential adverse effects. Long-term adherence is crucial for maintaining results.

Video content above is prompted by the following:

• Discuss the potential impact of untreated alopecia areata on a patient’s mental health, particularly in the adolescent patient population.
• What strategies can be used to address the psychosocial impact of alopecia areata in adolescents?

• How would you define the severity of this patient’s alopecia areata? How does the SALT score aid in determining severity and treatment approach?
• Describe your approach to pharmacologic treatment for this patient.
• What are your treatment goals, and how would you communicate these goals to the patient?
• What should this patient expect in terms of effectiveness with ritlecitinib? How would you discuss an expected timeline for hair regrowth with this patient and his family?
• What monitoring should be done before and during treatment with ritlecitinib?
• How would you discuss potential adverse effects of ritlecitinib with this patient? What should he and his family be aware of in terms of serious adverse events?
• Would you combine any other treatments (oral/topical minoxidil, oral/topical corticosteroids) with ritlecitinib?
• Discuss the importance of treatment adherence/persistence for ritlecitinib effectiveness. Will hair growth remain after treatment discontinuation?

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