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Maddi Hebebrand is an associate editor of 

and joined the MJH Life Sciences team in May 2024. She attended Baldwin Wallace University, studying Media Production and Film, and is now finishing her Masters in Digital Media through Ohio University. When she's not writing, Maddi loves to read, attend concerts and spend time with her family.

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According to the company, comparative tests revealed PN-881 surpasses or matches the efficacy of current injectable IL-17 therapies.

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and joined the MJH Life Sciences team in February 2023. She attended Kent State University and earned a Bachelor of Science degree in journalism with minors in public relations and creative writing. She enjoys making and listening to music, reading, and spending time with her cats, Astrid and Marceline.

The LIBERO study confirmed brodalumab is effective in managing psoriasis in patients over 100 kg, showing comparable long-term benefits in patients under 100 kg.

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Final Thoughts: The Importance of Comparative Studies in AD

Panelists offer concluding insights and emphasize the critical role of comparative studies in advancing atopic dermatitis treatment strategies.

clinical

Video Series

Considerations for Using Roflumilast in the Pediatric Population, and for Skin of Color

How do age restrictions for PDE4s impact your treatment decisions for pediatric patients with atopic dermatitis, and how do you address parental concerns about these options?

Roflumilast is also approved for psoriasis and seborrheic dermatitis. Please comment on the benefits of having one treatment option for multiple conditions when managing patients with overlapping inflammatory dermatologic issues.

In your opinion, is there an opportunity to simplify treatment with one PDE4 inhibitor for these inflammatory skin diseases?

What are the current guidelines for using topical corticosteroids in atopic dermatitis, and how might the availability of PDE4 inhibitors impact these guidelines? [

Looking ahead, what are your thoughts regarding the future for topical PDE4 inhibitors in dermatology?

Are you aware of emerging treatments or novel formulations on the horizon that could further change the landscape?

How do you integrate new agents like roflumilast into existing treatment paradigms? What factors influence your decision to incorporate newer treatments over well-established options?

When discussing topical PDE4 inhibitors with patients, what are your key considerations?

How do you guide them through the decision-making process, and what key points do you emphasize in patient education?

Age restrictions for PDE4 inhibitors in pediatric atopic dermatitis necessitate careful consideration of treatment options, balancing efficacy and safety. Roflumilast's approval for multiple conditions offers a streamlined approach for patients with overlapping dermatologic issues, potentially simplifying treatment regimens. Current guidelines for topical corticosteroids may evolve with the increased availability of PDE4 inhibitors, offering alternative therapeutic pathways. The future of topical PDE4 inhibitors in dermatology appears promising, with potential for novel formulations and emerging treatments. Integrating new agents like roflumilast requires weighing efficacy, safety, and patient-specific factors.

Panelists discuss how age restrictions for PDE4 inhibitors affect treatment decisions for pediatric patients with atopic dermatitis, addressing parental concerns and highlighting the benefits of a single treatment option like roflumilast for managing overlapping inflammatory dermatologic conditions; they also explore current guidelines for corticosteroid use, the potential impact of PDE4 inhibitors on these guidelines, and the future of topical PDE4 inhibitors in dermatology, including the integration of new agents into treatment paradigms and key considerations for patient education and decision-making.

Patient Education and Novel Topical Therapies for AD

Hyperhidrosis is not rare. According to the 

, approximately 385 million people worldwide live with hyperhidrosis.

In fact, they note that the amount of people living with chronic, excessive sweating is even higher than the amount of people living with other dermatologic conditions like psoriasis.

Just how common is hyperhidrosis in real-world comparisons?

The prevalence of hyperhidrosis is much higher in younger populations than in the general population, with 8.8% of individuals between the ages of 18 to 39 years old living with the condition. 

When comparing these statistics to everyday, common occurrences like hair color, the number of people with hyperhidrosis is greater than the 1% of individuals with natural red hair and 2% of individuals with natural blond hair. 

Despite how common hyperhidrosis is, it is estimated that 27% of those with the condition never receive a diagnosis.

 wants to hear from you. What percentage of the global population is estimated to have hyperhidrosis?

 to share your hyperhidrosis insights or research.

Albert. Fact check: Hyperhidrosis - International Hyperhidrosis Society: Official site. Home - International Hyperhidrosis Society. October 24, 1970. Accessed November 16, 2023. 

https://www.sweathelp.org/home/news-blog/542-fact-check-hyperhidrosis.html

Hyperhidrosis affects approximately 385 million people globally, surpassing the prevalence of other dermatologic conditions like psoriasis. It is notably more common in younger populations, with 8.8% of individuals aged 18 to 39 experiencing the condition. Comparatively, hyperhidrosis is more prevalent than natural red or blond hair, which affects 1% and 2% of the population, respectively. Despite its prevalence, 27% of those with hyperhidrosis remain undiagnosed. The article encourages engagement during Hyperhidrosis Awareness Month to share insights and research on the condition.

Click here to answer this week's poll for Hyperhidrosis Awareness Month.

Polls 

POLL: What Percent of the Global Population is Estimated to Have Hyperhidrosis?

Tiffany Mayo, MD, provides insights and practical tips in patient communication for the diagnosis and management of patients with hidradenitis suppurativa.

Hidradenitis Suppurativa: Practical Tips and Considerations Regarding Diagnosis, Treatment, and Patient Communication

Hi, and welcome to this Dermatology Times Partner Perspective video series. I’m Tiffany Mayo, associate professor, vice chair of diversity and inclusion, and director of the clinical research unit at the Heersink School of Medicine department of dermatology at the University of Alabama at Birmingham. In the first video, we discussed the clinical features, patient burden, and challenges of diagnosis of hidradenitis suppurativa, or HS. In this final video, I’ll wrap up the conversation with a few final thoughts.

This episode, "Hidradenitis Suppurativa: Practical Tips and Considerations Regarding Diagnosis, Treatment, and Patient Communication" is sponsored by Novartis, and I have been compensated for my time.

I mentioned in the first video that the average time of delay in HS diagnosis is 7 to 10 years.

 During this delay, patients see an average of 3 different providers and receive 3 misdiagnoses before receiving the correct diagnosis, which is typically given by a dermatologist.

 These are general statistics, but I can share here that most of my patients report similar real-world experiences. From the patient perspective, this delay causes frustration and distrust. From a disease management perspective, a delayed diagnosis can lead to greater difficulty in resolving HS symptoms and progression.

Upon diagnosis, it is important to name the condition and help the patient understand what it is and how and why it needs to be treated. Patients with HS frequently have questions that can culminate in a time-intensive visit, involving at least 30 minutes of extensive counseling and additional time for prior authorization of medications.

 It’s understandable that recurrent visits of this type may not be practical for all HCPs; however, we are all responsible for ensuring that patients are accurately diagnosed and are on the right track for optimal disease management. Collaborating with local HS experts or other physicians who can help manage the disease is key when this is the case. Because there can be a delay in access to these physicians, it is recommended to start patients on an initial regimen but inform them that they will require follow-up and, likely, treatment escalation that will be handled by a colleague you are able to name.

Resources are also available to help with patient education and disease management. Foundations such as the US and Canadian HS Foundations play an important role in educating patients and clinicians through symposiums and other efforts.

 There are many tools HCPs can find helpful, including prior authorization templates, treatment guidelines, and HS specialty clinic directories.

I would like to summarize this video series by reiterating HS is a chronic, painful disease with a substantial impact on patient quality of life. There is typically a delay in time to accurate diagnosis and the disease is often suboptimally managed. Though more work is needed, we can support our patients by helping them understand the disease and by appropriately managing it. Thank you to our viewers for watching.

 HS Foundation. Accessed May 6, 2024. https://www.hs-foundation.org/

Hidradenitis suppurativa (HS) is a chronic, painful condition with significant patient impact, often experiencing diagnostic delays of 7-10 years. Patients typically see multiple providers and receive misdiagnoses before a dermatologist correctly identifies HS. Effective management requires clear communication, patient education, and collaboration with HS specialists. Initial treatment regimens should be started promptly, with plans for follow-up and potential treatment escalation. Resources like the US and Canadian HS Foundations provide valuable support for both patients and healthcare providers, aiding in education and disease management.

 (HSF) offers a range of grant opportunities designed to advance research and clinical expertise in hidradenitis suppurativa (HS). These grants aim to support researchers at different career stages, from early investigators to established practitioners, by providing funding to develop new treatment insights, improve patient care, and stimulate innovative, translational research. Below is an overview of the available grants:

 This grant seeks to promote clinical and translational research projects that can meaningfully improve patient care in the field of HS. Researchers are invited to submit applications that propose new approaches to understanding HS, including studies on disease mechanisms, therapeutic strategies, or patient-centered care models. Award amounts range from $5,000 to $20,000, allowing researchers flexibility to design studies that fit their project scope. A minimum of five grants may be awarded annually, subject to funding availability. This grant is ideal for early-stage investigators, as priority is given to applicants who are new to HS research. 

 Aimed at encouraging novel research capable of attracting long-term funding from the National Institutes of Health (NIH) or similar agencies, this grant supports innovative approaches in HS research. Eligible researchers can apply for up to $75,000 to fund one-year projects. The goal is to bridge the gap between basic science and clinical practice, enabling researchers to conduct studies that have the potential to translate directly into improved patient outcomes. Applications are welcome from early-stage investigators and collaborative research teams within an institution. 

 This grant supports trainees and early-career faculty interested in gaining hands-on experience in managing HS under the guidance of an established HS expert. The award provides up to $4,000 to fund up to four weeks of mentored clinical practice and procedural training. This unique opportunity aims to nurture the next generation of HS specialists by creating pathways to learn from seasoned practitioners and enhance skills in clinical care, research, and patient education. Priority is given to applicants from areas without access to an HS clinic.

All applicants will be notified of acceptance at the American Academy of Dermatology Annual Meeting in March 2025.

For more information on each grant and application instructions, please visit the respective links provided.

The Hidradenitis Suppurativa Foundation (HSF) offers grants to advance research and clinical expertise in hidradenitis suppurativa (HS). These grants support researchers at various career stages, from early investigators to established practitioners, aiming to develop new treatment insights, improve patient care, and stimulate innovative research. The Danby Research Grant focuses on clinical and translational projects, the Translational Research Grant encourages novel research with potential for long-term funding, and the Mentored Experience Grant provides hands-on experience for trainees. Application deadlines are in December 2024 and January 2025.

The Hidradenitis Suppurativa Foundation offers grants for HS research and clinical expertise, supporting early-stage to established investigators.

Bobby Lazzara, MD

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