OS-01 Peptide Product Can Reduce Signs of Periorbital Skin Aging

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A novel peptide formulation, OS-01 EYE, has proven to be safe and effective for reducing signs of periorbital skin aging.¹ The clinical trial demonstrated positive short-term and long-term results at 4 and 12 weeks. Patients and clinicians saw a notable enhancement in skin hydration, firmness, elasticity, and radiance with a decline in fine lines, dark circles, and puffiness underneath the eyes.

The clinical study included 22 participants between the ages of 47 and 65. Of the sample, 16 were female and 6 were male. All had a Fitzpatrick skin type between I and III. Patients were instructed to apply a dime-sized amount twice daily. Each was also provided with a standardized skin care regimen of cleanser, moisturizer, and sunscreen to reduce variability.

The product contained a high concentration of senomorphic peptide OS-01, which enhances DNA repair and reduces skin DNA methylation age. This was combined with active ingredients like acetyl hexapeptide-8, Fucus vesiculosus extract, Moringa oleifera seed extract, and hyaluronic acid to boost collagen production and increase moisturization.

Evaluations occurred at baseline, week 4, and week 12. Investigators measured skin hydration, barrier function, firmness, and elasticity with bioinstrumental methods along with subjective 5-point patient questionaries. VISIA-CR photographs graded fine lines, wrinkles, puffiness, and dark circles. Results were verified through a post-hoc power analysis.

Positive clinical outcomes were noted in all measured categories. Transepidermal water loss (TEWL) decreased by 10.07% at week 4 and 17.33% at week 12. Hydration also increased at week 4. This percentage of 20.37% (p < 0.001) rose to 32.49% at week 12 (p < 0.001). Furthermore, skin firmness improved by 6.29% at week 4 and 10.19% at week 12 while elasticity increased by 13.75% at week 4 and 25.58% at week 12.

The appearance of fine lines and wrinkles was decreased in 45.45% of patients at week 4. This improved to a mean percent improvement of 6.87%. Puffiness was reduced in half of the participants at week 4. This also improved to a mean percent improvement of 10.90% (p < 0.001). Although no change in dark circles was observed at week 4, 50% of patients saw a statistically significant improvement by week 12 (p < 0.001).

95.46% of patients saw improvement in their overall appearance. More specifically, high percentages of participants noted positive changes in skin hydration, firmness, elasticity, hyperpigmentation, puffiness, smoothness, and radiance after just 4 weeks. Some parameters did decrease slightly at week 12 but researchers believe that patients may have scored lower for visible improvements if strong enhancements were already seen at week 4.

Blinded grading of the VISIA-CR images supports these quantitative findings. Reduced wrinkles, enhanced skin smoothness, and decreased puffiness were observed in almost half of the patients.

Additionally, no adverse events occurred and none of the patients discontinued product use. The OS-01 peptide’s safety was previously demonstrated by investigators both in vivo and ex vivo through a double-blinded, split-face clinical study.

It has been reported that the periorbital area ages faster than other regions on the face, especially due to the thinner epidermis and stratum corneum.² Because of this, more specialized treatment is needed for the skin around the eyes. The OS-O1 EYE serum can fulfill this need due to its potent and safe formulation.

“This clinical study provides compelling evidence for using the OS-01 peptide-containing formulation as a pro-longevity treatment for periorbital skin,” the authors concluded.

References

1. Zonari A, Brace LE, Li F, et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. Published online January 9, 2025. doi:10.1111/ics.13042

2. Flagler, M., Osorio, K., Kaczvinsky, J., Dowdy, A., Osborne, R., Rocchetta, H., ... & Zhao, S. (2016, May). New biological insights into skin aging around the eye. In JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (Vol. 74, No. 5, pp. AB28-AB28). 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA: MOSBY-ELSEVIER.