Navigating the Complexities of Generalized Pustular Psoriasis Diagnosis and Management
Aaron Farberg, MD; Tina Bhutani, MD, MAS; Christopher Bunick, MD, PhD; and Harrison Nguyen, MD, MBA, MPH, explore the complex challenges of identifying, treating, and managing generalized pustular psoriasis—a rare, potentially life-threatening condition characterized by widespread sterile pustules—discussing its profound quality-of-life impact, common triggers, evolution of treatments from traditional systemics to targeted biologics, clinical cases highlighting emergency management and maintenance approaches, and promising future directions in diagnostics and personalized therapies.
EP. 1: The Prevalence and Characteristics of GPP
Panelists discuss how generalized pustular psoriasis (GPP), while rare, presents with distinctive widespread sterile pustules on erythematous skin, requires prompt medical intervention, and differs significantly from more common plaque psoriasis in its clinical presentation, triggers, and treatment approaches.
EP. 2: Clinical Experience and Diagnosis of GPP
Panelists discuss how clinical experience in diagnosing generalized pustular psoriasis (GPP) requires recognizing its hallmark features of widespread sterile pustules on inflamed skin, distinguishing it from other pustular conditions, and understanding the genetic mutations and triggers that can precipitate this rare but potentially life-threatening form of psoriasis.
